Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451

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Effects of Daintain/AIF-1 on β Cell Dysfunction in INS-1 Cells
Xinyuan HUANGYanying ZHAOShaohui JIADongjing YANZhengwang CHEN
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JOURNAL FREE ACCESS Advance online publication

Article ID: 110317

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Abstract

We investigated the effects of daintain/AIF-1, a novel inflammatory cytokine, on INS-1β cells. Cells incubated with daintain/AIF-1 showed decreased cell viability and glucose-stimulated insulin secretion, as well as upregulated apoptosis and NO production. These deleterious effects of daintain/AIF-1 indicate that daintain/AIF-1 plays important roles in the dysfunction of pancreatic β cells in type-1 diabetes.

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© 2011 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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