Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997

Ling LIN; SiYang NI; LinZhuan WU; YiGuang WANG; YuCheng WANG; PeiZhen TAO; WeiQing HE; XiangJing WANG

doi:10.1271/bbb.110361

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Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997

Ling LIN, SiYang NI, LinZhuan WU, YiGuang WANG, YuCheng WANG, PeiZhen TAO, WeiQing HE, XiangJing WANG

著者情報

キーワード: biosynthesis, gdmP, geldanamycin, 4,5-dihydro-thiazinogeldanamycin

ジャーナルフリー早期公開

論文ID: 110361

DOI https://doi.org/10.1271/bbb.110361

この記事には本公開記事があります。

The final version of this article is now available: Vol. 75 (2011) , No. 10 p.2042

詳細

抄録

Novel geldanamycin derivative, 4,5-dihydro-thiazinogeldanamycin (3), was characterized from the gdmP mutant in Streptomyces hygroscopicus 17997, besides expected 4,5-dihydro-geldanamycin (2). The presence of this compound would suggest an unknown post-PKS modification in geldanamycin biosynthesis. Compound 3 exhibited moderate anti-HSV-1-virus activity and higher water solubility than geldanamycin (1). Cysteine served as a precursor to synthesize 3, whose formation required obligatory enzymatic assistance.

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