Synthesis of the Disialic Acid-Embedded Glycan Part of Ganglioside HPG-1

Hiroyo SHIMIZU; Yuki IWAYAMA; Akihiro IMAMURA; Hiromune ANDO; Hideharu ISHIDA; Makoto KISO

doi:10.1271/bbb.110619

This article has now been updated. Please use the final version.

Synthesis of the Disialic Acid-Embedded Glycan Part of Ganglioside HPG-1

Hiroyo SHIMIZU, Yuki IWAYAMA, Akihiro IMAMURA, Hiromune ANDO, Hideharu ISHIDA, Makoto KISO

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Keywords: ganglioside, sialic acid, echinoderm, neurogenic activity

JOURNAL FREE ACCESS Advance online publication

Article ID: 110619

DOI https://doi.org/10.1271/bbb.110619

The final version of this article is now available: Vol. 75 (2011) , No. 10 p.2079

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Abstract

Synthesis of tetrasaccharide portion of ganglioside HPG-1 is described. The tetrasaccharide sequence, Fuc-α(1,8)-Neu5Gc-α(2,4)-Neu5Ac-α(2,6)-Glc, was successfully assembled by a linear strategy, in which the 1,5-lactamized sialyl galactose acceptor and the 8-O-Lev-N-Troc-sialic acid donor were exploited as key units.

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