Hyuganatsu Orange (Citrus tamurana Hort. Ex Tanaka) Contains a Water Soluble Substance That Suppresses Bone Loss in Ovariectomized Rats

Masatoshi YAMAGUCHI; Hiroshi SAMESHIMA; Tsuyomu IKENOUE; Makoto TSUBOI; Muneaki HIDAKA; Kazuhiko ARIMORI

doi:10.1271/bbb.110625

This article has now been updated. Please use the final version.

Hyuganatsu Orange (Citrus tamurana Hort. Ex Tanaka) Contains a Water Soluble Substance That Suppresses Bone Loss in Ovariectomized Rats

Masatoshi YAMAGUCHI, Hiroshi SAMESHIMA, Tsuyomu IKENOUE, Makoto TSUBOI, Muneaki HIDAKA, Kazuhiko ARIMORI

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Keywords: Citrus tamurana, osteoporosis, bone mineral density, rat-preosteoclast cells, tartrate-resistant acid phosphatase positive cells

JOURNAL FREE ACCESS Advance online publication

Article ID: 110625

DOI https://doi.org/10.1271/bbb.110625

The final version of this article is now available: Vol. 76 (2012) , No. 2 p.364

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Abstract

We investigated whether Hyuganatsu orange (Citrus tamurana Hort. ex Tanaka) contains water and acetic-acid soluble substances that increase bone mineral density (BMD) in ovariectomized rats. In in vivo study, femoral BMD can significantly increased. In in vitro study, tartrate-resistant acid phosphatase (TRAP) positive cells significantly decreased. We speculate that Hyuganatsu orange contains biologically active substances other than hesperidin that increase BMD.

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