Sudachitin, a Polymethoxyflavone from Citrus sudachi, Suppresses Lipopolysaccharide-Induced Inflammatory Responses in Mouse Macrophage-Like RAW264 Cells

Keizo YUASA; Kaori TADA; Genki HARITA; Tomomi FUJIMOTO; Masao TSUKAYAMA; Akihiko TSUJI

doi:10.1271/bbb.110800

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Sudachitin, a Polymethoxyflavone from Citrus sudachi, Suppresses Lipopolysaccharide-Induced Inflammatory Responses in Mouse Macrophage-Like RAW264 Cells

Keizo YUASA, Kaori TADA, Genki HARITA, Tomomi FUJIMOTO, Masao TSUKAYAMA, Akihiko TSUJI

著者情報

キーワード: sudachitin, polymethoxyflavone, anti-inflammation, nitric oxide (NO)

ジャーナルフリー早期公開

論文ID: 110800

DOI https://doi.org/10.1271/bbb.110800

この記事には本公開記事があります。

The final version of this article is now available: Vol. 76 (2012) , No. 3 p.598

詳細

抄録

Although some polymethoxyflavones possess several important biological properties, including neuroprotective, anticancer, and anti-inflammatory ones, sudachitin, a polymethoxyflavone from Citrus sudachi, has been little studied. In this study, we found that sudachitin inhibited nitric oxide production by suppressing the expression of inducible nitric oxide synthase in lipopolysaccharide-stimulated macrophages, indicating that sudachitin has an anti-inflammatory effect.

責任著者(Corresponding author)

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