Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451

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Rhapontigenin Converted from Rhapontin Purified from Rheum undulatum Enhances the Inhibition of Melanin Synthesis
Hyun-Sun LEE, Jeong-Keun KIM, Keun-Tae PARK, Young-Hee LIM
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JOURNAL FREE ACCESS Advance online publication

Article ID: 120229

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Abstract
Rhapontigenin was produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation. Rhapontin and rhapontigenin exhibited dose-dependent inhibition of tyrosinase activity and melanin synthesis in B16F10 melanoma cells, but the inhibitory activity of rhapontigenin was greater than that of rhapontin. Thus the bioconversion of rhapontin enhanced its ability to inhibit cellular tyrosinase activity and melanin synthesis.
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© 2012 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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