Santonin-Related Compound 2 Inhibits the Nuclear Translocation of NF-κB Subunit p65 by Targeting Cysteine 38 in TNF-α-Induced NF-κB Signaling Pathway

Ryuichi TAMURA; Kyoko MORIMOTO; Seiya HIRANO; Liyan WANG; Ming ZHAO; Masayoshi ANDO; Takao KATAOKA

doi:10.1271/bbb.120619

This article has now been updated. Please use the final version.

Santonin-Related Compound 2 Inhibits the Nuclear Translocation of NF-κB Subunit p65 by Targeting Cysteine 38 in TNF-α-Induced NF-κB Signaling Pathway

Ryuichi TAMURA, Kyoko MORIMOTO, Seiya HIRANO, Liyan WANG, Ming ZHAO, Masayoshi ANDO, Takao KATAOKA

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Keywords: eudesmane, nuclear factor κB, santonin-related compound 2, sesquiterpene lactone, tumor necrosis factor-α

JOURNAL FREE ACCESS Advance online publication

Article ID: 120619

DOI https://doi.org/10.1271/bbb.120619

The final version of this article is now available: Vol. 76 (2012) , No. 12 p.2360

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Abstract

(11S)-2α-Bromo-3-oxoeudesmano-12,6α-lactone, designated santonin-related compound 2 (SRC2), only weakly affected IκBα degradation after tumor necrosis factor-α (TNF-α) stimulation, but strongly blocked the nuclear translocation of nuclear factor κB (NF-κB) subunit p65. Replacement of Cys-38 of p65 with serine abolished the inhibitory effect of SRC2 on this TNF-α-induced nuclear translocation. These results indicate that SRC2 inhibits the nuclear translocation of p65 by targeting Cys-38.

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