The Role of Acetylation in the Subcellular Localization of an Oncogenic Isoform of Translation Factor eIF5A

Muhammad ISHFAQ; Kazuhiro MAETA; Satoko MAEDA; Toru NATSUME; Akihiro ITO; Minoru YOSHIDA

doi:10.1271/bbb.120620

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The Role of Acetylation in the Subcellular Localization of an Oncogenic Isoform of Translation Factor eIF5A

Muhammad ISHFAQ, Kazuhiro MAETA, Satoko MAEDA, Toru NATSUME, Akihiro ITO, Minoru YOSHIDA

著者情報

キーワード: eIF5A2, acetylation, hypusination, subcellular localization, HDAC

ジャーナルフリー早期公開

論文ID: 120620

DOI https://doi.org/10.1271/bbb.120620

この記事には本公開記事があります。

The final version of this article is now available: Vol. 76 (2012) , No. 11 p.2165

詳細

抄録

Mammalian cells express two isoforms of eIF5A, eIF5A1 and eIF5A2, but little is known about the function of eIF5A2. Here we report that eIF5A2 was reversibly acetylated at lysine-47. HDAC6 and SIRT2 were identified as the enzymes responsible for deacetylating eIF5A2. Analysis using acetylation-deficient mutants indicated that acetylation regulates the subcellular localization of eIF5A2.

責任著者(Corresponding author)

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