Involvement of 5-Methyltetrahydrofolate in the Amelioration of Hyperhomocysteinemia Caused by Vitamin B6 Deficiency and <small>L</small>-Methionine Supplementation

Kohei YAMAMOTO; Yasuka ISA; Tomoyuki NAKAGAWA; Takashi HAYAKAWA

doi:10.1271/bbb.120661

This article has now been updated. Please use the final version.

Involvement of 5-Methyltetrahydrofolate in the Amelioration of Hyperhomocysteinemia Caused by Vitamin B₆ Deficiency and L-Methionine Supplementation

Kohei YAMAMOTO, Yasuka ISA, Tomoyuki NAKAGAWA, Takashi HAYAKAWA

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Keywords: vitamin B₆ deficiency, hyperhomocysteinemia, methionine synthase, 5-methyltetrahydrofolate, post-methionine load

JOURNAL FREE ACCESS Advance online publication

Article ID: 120661

DOI https://doi.org/10.1271/bbb.120661

The final version of this article is now available: Vol. 77 (2013) , No. 2 p.378

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Abstract

We attempted to clarify the reason why folate fortification ameliorates hyperhomocysteinemia induced by vitamin B₆ deficiency. Hyperhomocysteinemia caused by vitamin B₆ deficiency significantly decreased the rat liver 5-methyltetrahydrofolate level which was significantly improved by folate fortification. This result suggests that the amelioration of hyperhomocysteinemia in response to folate supplementation had enhanced the removal of homocysteine via methionine synthase.

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