Involvement of 5-Methyltetrahydrofolate in the Amelioration of Hyperhomocysteinemia Caused by Vitamin B6 Deficiency and <small>L</small>-Methionine Supplementation

Kohei YAMAMOTO; Yasuka ISA; Tomoyuki NAKAGAWA; Takashi HAYAKAWA

doi:10.1271/bbb.120661

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Involvement of 5-Methyltetrahydrofolate in the Amelioration of Hyperhomocysteinemia Caused by Vitamin B₆ Deficiency and L-Methionine Supplementation

Kohei YAMAMOTO, Yasuka ISA, Tomoyuki NAKAGAWA, Takashi HAYAKAWA

著者情報

キーワード: vitamin B₆ deficiency, hyperhomocysteinemia, methionine synthase, 5-methyltetrahydrofolate, post-methionine load

ジャーナルフリー早期公開

論文ID: 120661

DOI https://doi.org/10.1271/bbb.120661

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013) , No. 2 p.378

詳細

抄録

We attempted to clarify the reason why folate fortification ameliorates hyperhomocysteinemia induced by vitamin B₆ deficiency. Hyperhomocysteinemia caused by vitamin B₆ deficiency significantly decreased the rat liver 5-methyltetrahydrofolate level which was significantly improved by folate fortification. This result suggests that the amelioration of hyperhomocysteinemia in response to folate supplementation had enhanced the removal of homocysteine via methionine synthase.

責任著者(Corresponding author)

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