Isolation and Characterization of an Anti-Insect β-Toxin from the Venom of the Scorpion Isometrus maculatus

Tomoyuki KAWACHI; Masahiro MIYASHITA; Yoshiaki NAKAGAWA; Hisashi MIYAGAWA

doi:10.1271/bbb.120697

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Isolation and Characterization of an Anti-Insect β-Toxin from the Venom of the Scorpion Isometrus maculatus

Tomoyuki KAWACHI, Masahiro MIYASHITA, Yoshiaki NAKAGAWA, Hisashi MIYAGAWA

著者情報

キーワード: scorpion β-toxin, insect toxicity, HPLC, de novo sequencing, Edman degradation

ジャーナルフリー早期公開

論文ID: 120697

DOI https://doi.org/10.1271/bbb.120697

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013) , No. 1 p.205

詳細

抄録

Im-3 was isolated from the venom of the scorpion Isometrus maculatus through several steps of HPLC fractionation based on the insect paralytic activity. Injecting Im-3 into crickets induced paralysis, but no toxicity was apparent in mice after an intracerebroventricular injection. Im-3 shares sequence similarity to scorpion β-toxins that specifically affect insect sodium channels.

責任著者(Corresponding author)

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