Differential Dose Response of mTOR Signaling to Oral Administration of Leucine in Skeletal Muscle and Liver of Rats

Fumiaki YOSHIZAWA; Shinji MOCHIZUKI; Kunio SUGAHARA

doi:10.1271/bbb.120737

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Differential Dose Response of mTOR Signaling to Oral Administration of Leucine in Skeletal Muscle and Liver of Rats

Fumiaki YOSHIZAWA, Shinji MOCHIZUKI, Kunio SUGAHARA

著者情報

キーワード: leucine, eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), 70-kDa ribosomal protein S6 kinase (S6K1), liver, skeletal muscle

ジャーナルフリー早期公開

論文ID: 120737

DOI https://doi.org/10.1271/bbb.120737

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013) , No. 4 p.839

詳細

抄録

Phosphorylation of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and 70-kDa ribosomal protein S6 kinase (S6K1) in the rat liver increased in proportion to the amount of leucine administered, ranging from 0.169 to 1.35 g/kg of body weight. In the skeletal muscle, phosphorylation of these factors reached a plateau at 0.675 g/kg of body weight. The sensitivity of mammalian target of rapamycin (mTOR) signaling to leucine in the skeletal muscle appeared to be higher than that in the liver.

責任著者(Corresponding author)

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