Influence of GABA on Brain Protein Synthesis Mediated by the Mammalian Target on the Rapamycin Pathway

Panicha THANAPREEDAWAT; Miho OHSUMI; Kazutoshi HAYASE; Fumiaki YOSHIZAWA; Hidehiko YOKOGOSHI

doi:10.1271/bbb.120808

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Influence of GABA on Brain Protein Synthesis Mediated by the Mammalian Target on the Rapamycin Pathway

Panicha THANAPREEDAWAT, Miho OHSUMI, Kazutoshi HAYASE, Fumiaki YOSHIZAWA, Hidehiko YOKOGOSHI

著者情報

キーワード: γ-aminobutyric acid (GABA), mammalian target of rapamycin (mTOR), S6K1, growth hormone, protein synthesis

ジャーナルフリー早期公開

論文ID: 120808

DOI https://doi.org/10.1271/bbb.120808

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013) , No. 3 p.660

詳細

抄録

This study determined the influence of γ-aminobutyric acid (GABA) on brain protein synthesis via the mammalian target of rapamycin (mTOR) pathway. Experiments were carried out on three groups of 6-wk-old male rats with 0%, 0.5%, and 1% GABA. The percentage-phosphorylated S6K1 and growth hormone (GH) concentration was significantly increased by the GABA administration. The insulin level was not significantly changed, while the insulin-like growth factor 1 (IGF-1) level was significantly decreased by the GABA administration.

責任著者(Corresponding author)

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