Rapid Induction of an Immune Response in Rat Peyer's Patch after Oral Administration of Enterococcus faecalis Strain EC-12

Ryo INOUE; Takamitsu TSUKAHARA; Noriko MATSUKAWA; Takumi WATANABE; Wakoto BUKAWA; Keizo NAKAYAMA; Kazunari USHIDA

doi:10.1271/bbb.120838

This article has now been updated. Please use the final version.

Rapid Induction of an Immune Response in Rat Peyer's Patch after Oral Administration of Enterococcus faecalis Strain EC-12

Ryo INOUE, Takamitsu TSUKAHARA, Noriko MATSUKAWA, Takumi WATANABE, Wakoto BUKAWA, Keizo NAKAYAMA, Kazunari USHIDA

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Keywords: lactic acid bacteria, Peyer's patch, immune response, rat

JOURNAL FREE ACCESS Advance online publication

Article ID: 120838

DOI https://doi.org/10.1271/bbb.120838

The final version of this article is now available: Vol. 77 (2013) , No. 4 p.863

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Abstract

A rapid and sharp immune response induced in Peyer's patches (PPs) by a single gavage of a heat-killed Enterococcus faecalis strain EC-12 (EC-12) was demonstrated. EC-12 was observed inside the PPs 2.5 h post administration and induction of TNF-α and CD69 gene expression was observed at the same time. The immune response in PPs disappeared 24 h post administration.

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