Inhibition of Amyloid β Aggregation by Acteoside, a Phenylethanoid Glycoside

Manami KURISU; Yusaku MIYAMAE; Kazuma MURAKAMI; Junkyu HAN; Hiroko ISODA; Kazuhiro IRIE; Hideyuki SHIGEMORI

doi:10.1271/bbb.130101

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Inhibition of Amyloid β Aggregation by Acteoside, a Phenylethanoid Glycoside

Manami KURISU, Yusaku MIYAMAE, Kazuma MURAKAMI, Junkyu HAN, Hiroko ISODA, Kazuhiro IRIE, Hideyuki SHIGEMORI

著者情報

キーワード: acteoside, amyloid β, aggregation, Alzheimer's disease, phenylethanoid glycoside

ジャーナルフリー早期公開

論文ID: 130101

DOI https://doi.org/10.1271/bbb.130101

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013) , No. 6 p.1329

詳細

抄録

We examined the effects of acteoside (1a), which was isolated from Orobanche minor, and its derivatives on the aggregation of a 42-mer amyloid β protein (Aβ42) in our search for anti-amyloidogenic compounds for Alzheimer's disease (AD) therapy. Acteoside (1a) strongly inhibited the aggregation of Aβ42 in a dose-dependent manner. The structure-activity relationship for acteoside (1a) and related compounds suggests the catechol moiety of phenylethanoid glycosides to be essential for this inhibitory activity.

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