Isolation and Structural Determination of Makinolide B from Streptomyces sp. MK-19

Michitaka HIDAKI; Mitsuru YOSHIDA; Naoto OGAWA; Shinya KODANI

doi:10.1271/bbb.130204

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Isolation and Structural Determination of Makinolide B from Streptomyces sp. MK-19

Michitaka HIDAKI, Mitsuru YOSHIDA, Naoto OGAWA, Shinya KODANI

著者情報

キーワード: Streptomyces, macrolide, bafilomycin analogue, NMR spectrum

ジャーナルフリー早期公開

論文ID: 130204

DOI https://doi.org/10.1271/bbb.130204

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013), No. 9 pp. 1964-1966

詳細

抄録

A new 16-membered macrolide named makinolide B (1) was isolated from Streptomyces sp. MK-19. The structure of makinolide B (1) was determined on the basis of 2D NMR experiments involving DQF-COSY, TOCSY, HSQC, and HMBC methods. Application of the paper disk diffusion method to makinolide B (1) showed weak antibacterial activity against Staphylococcus aureus at the dose of 100 µg/disk.

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