A Hair Growth-Promoting Effect of Chinese Black Tea Extract in Mice

I-Ching HOU; Yasuyuki OI; Hiroyuki FUJITA; Yoshihisa YANO; Harukazu FUKAMI; Masaaki YOSHIKAWA

doi:10.1271/bbb.130298

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A Hair Growth-Promoting Effect of Chinese Black Tea Extract in Mice

I-Ching HOU, Yasuyuki OI, Hiroyuki FUJITA, Yoshihisa YANO, Harukazu FUKAMI, Masaaki YOSHIKAWA

著者情報

キーワード: hair growth, Chinese black tea extract (CBTE), estrogen receptor, C3H/He mice, capsaicin

ジャーナルフリー早期公開

論文ID: 130298

DOI https://doi.org/10.1271/bbb.130298

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013) , No. 7 p.1606

詳細

抄録

Chinese black tea extract (CBTE) fermented with Aspergillus sp. significantly promoted hair growth after 2 weeks of topical application in shaved 6 week-old male C3H/He mice. The hair growth-promoting effect of CBTE was potentiated synergistically by capsaicin, which has no effect on hair growth by itself. CBTE displayed an affinity for estrogen receptor (ER)α, with an IC₅₀ value of 74.8 µg/mL. This effect of CBTE might be mediated by the ERs, since a similar effect induced by orally administered soy isoflavone, a mixture of ERs ligands, has been reported to be synergistically potentiated by capsaicin.

責任著者(Corresponding author)

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