Inhibited Apoptosis of C₂C₁₂ Myoblasts by a Eupatorium chinense var. simplicifolium Root Extract

抄録

We investigated the effects of a Eupatorium chinense var. simplicifolium (EUC) root extract on muscle disorders and explored the underlying mechanism for oxidative stress-induced C₂C₁₂ myoblast damage. An EUC pre-treatment reduced the decreased cell viability after an H₂O₂ treatment. The heat shock protein (HSP) 70 level increased, and the phosphorylation of Jun amino-terminal kinases (JNKs) decreased in the EUC-pre-treated C₂C₁₂ myoblasts. The results of the present study demonstrate the potential benefit of a herbal medicine in treating oxidative stress-related muscle disorders.