Inhibition of Postprandial Hyperglycemia by Either an Insulin-Dependent or -Independent Drug Reduces the Expression of Genes Related to Inflammation in Peripheral Leukocytes of OLETF Rats

Chihiro IMAI; Tomomi HARAZAKI; Seiya INOUE; Kazuki MOCHIZUKI; Toshinao GODA

doi:10.1271/bbb.130451

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Inhibition of Postprandial Hyperglycemia by Either an Insulin-Dependent or -Independent Drug Reduces the Expression of Genes Related to Inflammation in Peripheral Leukocytes of OLETF Rats

Chihiro IMAI, Tomomi HARAZAKI, Seiya INOUE, Kazuki MOCHIZUKI, Toshinao GODA

著者情報

キーワード: postprandial hyperglycemia, inflammatory cytokine, peripheral leukocytes, α-glucosidase inhibitor, dipeptidyl peptidase-4 (DPP-4) inhibitor

ジャーナルフリー早期公開

論文ID: 130451

DOI https://doi.org/10.1271/bbb.130451

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013), No. 11 pp. 2305-2308

詳細

抄録

Treatment with the dipeptidyl peptidase-4 inhibitor, anagliptin, or with the α-glucosidase inhibitor, miglitol, reduced the oral sucrose load-inducible expression of interleukin (IL)-1β, IL-18, tumor necrosis factor-α, S100a8, S100a9, S100a11, IL-1R2, IL-1Rn and tumor necrosis factor receptor 2 genes in peripheral leukocytes of Otsuka Long-Evans Tokushima fatty (OLETF) rats at the stage of impaired glucose tolerance. Inhibiting postprandial hyperglycemia reduced the expression of genes related to inflammation in peripheral leukocytes of OLETF rats.

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