Vasodilating Effect of Di-Peptides in Thoracic Aortas from Spontaneously Hypertensive Rats

Mitsuru TANAKA; Toshiro MATSUI; Yusuke USHIDA; Kiyoshi MATSUMOTO

doi:10.1271/bbb.60119

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Vasodilating Effect of Di-Peptides in Thoracic Aortas from Spontaneously Hypertensive Rats

Mitsuru TANAKA, Toshiro MATSUI, Yusuke USHIDA, Kiyoshi MATSUMOTO

著者情報

キーワード: hypertension, ACE, vascular relaxation, small peptides, spontaneously hypertensive rat (SHR) aorta

ジャーナルフリー早期公開

論文ID: 60119

DOI https://doi.org/10.1271/bbb.60119

この記事には本公開記事があります。

The final version of this article is now available: Vol. 70 (2006) , No. 9 p.2292

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抄録

In this study, we found that antihypertensive di-peptide Val-Tyr (VY) showed a vascular relaxation effect in KCl-induced contraction of thoracic aorta rings from 18-week-old spontaneously hypertensive rats among di-peptides of VY, Ile-Tyr, and Tyr-Val irrespective of their angiotensin I-converting enzyme inhibitory activity. The effect was endothelium-independent, and was closely associated with vascular responses in the vascular smooth muscle layer.

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