Activation Effects of Allium tuberoum Rottl. on Choline Acetyltransferase

Mi Jeong KIM; Soo Jung CHOI; Hye Kyung KIM; Chang-Ju KIM; Bumshik HONG; Young Jun KIM; Dong-Hoon SHIN

doi:10.1271/bbb.60314

This article has now been updated. Please use the final version.

Activation Effects of Allium tuberoum Rottl. on Choline Acetyltransferase

Mi Jeong KIM, Soo Jung CHOI, Hye Kyung KIM, Chang-Ju KIM, Bumshik HONG, Young Jun KIM, Dong-Hoon SHIN

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Keywords: Allium tuberosum Rottl., choline acetyltransferase (ChAT), ferulic acid [4-hydroxy-3-methoxycinnamic acid], Alzheimer’s disease, acetylcholine (Ach)

JOURNAL FREE ACCESS Advance online publication

Article ID: 60314

DOI https://doi.org/10.1271/bbb.60314

The final version of this article is now available: Vol. 71 (2007) , No. 1 p.226

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Abstract

An ethanolic extract of Allium tuberosum Rottl. demonstrated potent choline acetytrasferase (ChAT) activating activity (45%) among 30 screened Korean edible plants. The ChAT activator of A. tuberoum Rottl. was purified and identified as ferulic acid [4-hydroxy-3-methoxycinnamic acid] via silica-gel open-column chromatography, HPLC, EI-MS, and ¹H/¹³C-NMR. The ferulic acid from A. tuberoum Rottl. exhibited ChAT activity in a dose-dependent manner and showed notoxicity in a cell viability assay (MTT assay). We suggest that the ferulic acid from A. tuberoum Rottl. was the strong ChAT activator.

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