Activation Effects of Allium tuberoum Rottl. on Choline Acetyltransferase

Mi Jeong KIM; Soo Jung CHOI; Hye Kyung KIM; Chang-Ju KIM; Bumshik HONG; Young Jun KIM; Dong-Hoon SHIN

doi:10.1271/bbb.60314

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Activation Effects of Allium tuberoum Rottl. on Choline Acetyltransferase

Mi Jeong KIM, Soo Jung CHOI, Hye Kyung KIM, Chang-Ju KIM, Bumshik HONG, Young Jun KIM, Dong-Hoon SHIN

著者情報

キーワード: Allium tuberosum Rottl., choline acetyltransferase (ChAT), ferulic acid [4-hydroxy-3-methoxycinnamic acid], Alzheimer’s disease, acetylcholine (Ach)

ジャーナルフリー早期公開

論文ID: 60314

DOI https://doi.org/10.1271/bbb.60314

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 1 p.226

詳細

抄録

An ethanolic extract of Allium tuberosum Rottl. demonstrated potent choline acetytrasferase (ChAT) activating activity (45%) among 30 screened Korean edible plants. The ChAT activator of A. tuberoum Rottl. was purified and identified as ferulic acid [4-hydroxy-3-methoxycinnamic acid] via silica-gel open-column chromatography, HPLC, EI-MS, and ¹H/¹³C-NMR. The ferulic acid from A. tuberoum Rottl. exhibited ChAT activity in a dose-dependent manner and showed notoxicity in a cell viability assay (MTT assay). We suggest that the ferulic acid from A. tuberoum Rottl. was the strong ChAT activator.

責任著者(Corresponding author)

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