Structure-Activity Relationship Study of the Bacterial Actin-Like Protein MreB Inhibitors: Effects of Substitution of Benzyl Group in S-Benzylisothiourea

Noritaka IWAI; Takuya FUJII; Hirokatsu NAGURA; Masaaki WACHI; Tomoya KITAZUME

doi:10.1271/bbb.60443

This article has now been updated. Please use the final version.

Structure-Activity Relationship Study of the Bacterial Actin-Like Protein MreB Inhibitors: Effects of Substitution of Benzyl Group in S-Benzylisothiourea

Noritaka IWAI, Takuya FUJII, Hirokatsu NAGURA, Masaaki WACHI, Tomoya KITAZUME

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Keywords: A22, actin-like protein, benzylisothiourea, MreB, rod-shape determination

JOURNAL FREE ACCESS Advance online publication
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Article ID: 60443

DOI https://doi.org/10.1271/bbb.60443

The final version of this article is now available: Vol. 71 (2007) , No. 1 p.246

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Abstract

We comprehensively investigated the effects of substitution of the benzyl group in S-benzylisothiourea derivatives on antibacterial activity, because we found previously that some substitutions enhanced it. A 2,4-Cl₂-derivative was found to be the most effective compound, it was stronger than the original one in Gram-negative rod shaped-bacteria such as Escherichia coli and Salmonella typhimurium.

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