Effect of Royal Jelly on Bisphenol A-Induced Proliferation of Human Breast Cancer Cells

Mako NAKAYA; Hiroyuki ONDA; Kyoko SASAKI; Akiko YUKIYOSHI; Hirofumi TACHIBANA; Koji YAMADA

doi:10.1271/bbb.60453

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Effect of Royal Jelly on Bisphenol A-Induced Proliferation of Human Breast Cancer Cells

Mako NAKAYA, Hiroyuki ONDA, Kyoko SASAKI, Akiko YUKIYOSHI, Hirofumi TACHIBANA, Koji YAMADA

著者情報

Mako NAKAYA
Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
Research Fellowship Division, Japan Society for the Promotion of Science
Hiroyuki ONDA
Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
Kyoko SASAKI
Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
Akiko YUKIYOSHI
Yamada Apiculture Center, Inc.
Hirofumi TACHIBANA
Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
Laboratory of Functional Food Design, Department of Functional Metabolic Design, Bio-Architecture Center, Kyushu University
Koji YAMADA
Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University

キーワード: royal jelly, breast cancer cell, bisphenol A

ジャーナルフリー早期公開

論文ID: 60453

DOI https://doi.org/10.1271/bbb.60453

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 1 p.253

詳細

抄録

Royal jelly is known as a functional food containing many useful minerals. In this study, we found an anti-environmental estrogen activity of royal jelly. Bisphenol A (BPA) is an environmental estrogen that stimulates proliferation of human breast cancer MCF-7 cells. Royal jelly inhibited the growth-promoting effect of BPA on MCF-7 cells, even though it did not affect the proliferation of cells in the absence of BPA. In addition, this inhibiting effect of royal jelly was heat-stable.

責任著者(Corresponding author)

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