Inhibitory Activity of Linoleic Acid Isolated from Proso and Japanese Millet toward Histone Deacetylase

抄録

Linoleic acid was isolated from both the methanol extracts of proso and Japanese millet as a histone deacetylase inhibitor. It showed uncompetitive inhibitory activity toward histone deacetylase (IC₅₀=0.51 mM) and potent cytotoxicity toward human leukemia K562 (IC₅₀=68 μM) and prostate cancer LNCaP cells (IC₅₀=193 μM). Millet containing linoleic acid might have anti-tumor activity.