Involvement of Extracellular Signal-Regulated Kinase in Nobiletin-Induced Melanogenesis in Murine B16/F10 Melanoma Cells

Hoon-Seok YOON; Sun-Ryung LEE; Hee-Chul KO; Soo-Youn CHOI; Ji-Gweon PARK; Jeong-Kook KIM; Se-Jae KIM

doi:10.1271/bbb.70088

This article has now been updated. Please use the final version.

Involvement of Extracellular Signal-Regulated Kinase in Nobiletin-Induced Melanogenesis in Murine B16/F10 Melanoma Cells

Hoon-Seok YOON, Sun-Ryung LEE, Hee-Chul KO, Soo-Youn CHOI, Ji-Gweon PARK, Jeong-Kook KIM, Se-Jae KIM

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Keywords: nobiletin, melanogenesis, extracellular signal-regulated kinase (ERK), tyrosinase

JOURNAL FREE ACCESS Advance online publication

Article ID: 70088

DOI https://doi.org/10.1271/bbb.70088

The final version of this article is now available: Vol. 71 (2007) , No. 7 p.1781

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Abstract

Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.

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