Kinetics of the Ceramide Kinase Inhibitor K1, a Suppressor of Mast-Cell Activation

Hirotaka KUMADA; Susumu MITSUTAKE; Yuichi INAGAKI; Shino MITSUNAGA; Hiroshi TSUCHIKAWA; Shigeo KATSUMURA; Yasuyuki IGARASHI

doi:10.1271/bbb.70308

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Kinetics of the Ceramide Kinase Inhibitor K1, a Suppressor of Mast-Cell Activation

Hirotaka KUMADA, Susumu MITSUTAKE, Yuichi INAGAKI, Shino MITSUNAGA, Hiroshi TSUCHIKAWA, Shigeo KATSUMURA, Yasuyuki IGARASHI

著者情報

キーワード: ceramide, ceramide kinase, ceramide 1-phosphate, sphingolipid

ジャーナルフリー早期公開

論文ID: 70308

DOI https://doi.org/10.1271/bbb.70308

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 10 p.2581

詳細

抄録

In a previous study, we synthesized a novel inhibitor of ceramide kinase, K1. In this study, we determined that inhibition by K1 is non-competitive and that four intact six-membered rings are important to the inhibitory activity. Furthermore, we identified an effective in vivo concentration for K1, at which it did not influence any cellular lipid synthesis other than that of ceramide 1-phosphate (C1P) using RBL-2H3 cells, and found that K1 suppressed the activation of mast cells.

責任著者(Corresponding author)

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