Reaction of Retinol with Peroxynitrite

Rie SUZUKI; Aditya KULKARNI; Yuya YOMODA; Hirokazu KAWAGISHI; Yukimasa TERADA; Takashi MAOKA; Hideo ETOH

doi:10.1271/bbb.70349

This article has now been updated. Please use the final version.

Reaction of Retinol with Peroxynitrite

Rie SUZUKI, Aditya KULKARNI, Yuya YOMODA, Hirokazu KAWAGISHI, Yukimasa TERADA, Takashi MAOKA, Hideo ETOH

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Keywords: retinol, peroxynitrite, antioxidative compounds

JOURNAL FREE ACCESS Advance online publication

Article ID: 70349

DOI https://doi.org/10.1271/bbb.70349

The final version of this article is now available: Vol. 71 (2007) , No. 10 p.2596

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Abstract

The reactivity of retinol with peroxynitrite, which is a strong oxidant and has been reported to induce several biological damages, was investigated. 13-cis-14-nitroretinol (1), 13-trans-14-nitroretinol (2), 13-apo-β-carotenone (3), retinal (4), 11,14-epoxyretinol (5), and 11,15-epoxyretinol (6) were identified as reaction products of retinol with peroxynitrite. From these results, it was observed that retinol can undergo a nitration reaction with peroxynitrite. Furthermore, the formation mechanisms of 1, 2, and 3 from retinol with peroxynitrite are discussed.

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