Effects of Citrus unshiu Powder on the Cytokine Balance in Peripheral Blood Mononuclear Cells of Patients with Seasonal Allergic Rhinitis to Pollen

Soichi TANABE; Yuki KINUTA; Hatsumi YASUMATSU; Masayoshi TAKAYANAGI; Shoko KOBAYASHI; Naondo TAKIDO; Masanori SUGIYAMA

doi:10.1271/bbb.70397

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Effects of Citrus unshiu Powder on the Cytokine Balance in Peripheral Blood Mononuclear Cells of Patients with Seasonal Allergic Rhinitis to Pollen

Soichi TANABE, Yuki KINUTA, Hatsumi YASUMATSU, Masayoshi TAKAYANAGI, Shoko KOBAYASHI, Naondo TAKIDO, Masanori SUGIYAMA

著者情報

キーワード: anti-allergic effect, rhinitis to pollen, Citrus unshiu, cytokine, PBMC

ジャーナルフリー早期公開

論文ID: 70397

DOI https://doi.org/10.1271/bbb.70397

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 11 p.2852

詳細

抄録

We evaluated the effects of a 50% methanol extract of Citrus unshiu powder (MEC) on cytokines in peripheral blood mononuclear cells (PBMCs) obtained from patients with seasonal allergic rhinitis to cedar pollen. The levels of cytokines, such as TNF-α, IFN-γ, IL-2, IL-4, IL-5, IL-10, IL-12 (p70), IL-13, and GM-CSF, produced by pollen-stimulated PBMC were measured. We found that MEC suppressed pollen-induced TNF-α release and increased IFN-γ release from PBMCs. The results suggest that Citrus unshiu powder has an immunomodulatory effect in vitro and that its use could improve seasonal allergic rhinitis symptoms.

責任著者(Corresponding author)

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