Inhibitory Effects of Egg Yolk Soluble Protein on Bone Resorption

Hye Kyung KIM; Myung-Gyou KIM; Kang-Hyun LEEM

doi:10.1271/bbb.70491

This article has now been updated. Please use the final version.

Inhibitory Effects of Egg Yolk Soluble Protein on Bone Resorption

Hye Kyung KIM, Myung-Gyou KIM, Kang-Hyun LEEM

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Keywords: yolk soluble protein, osteoclasts, differentiation, bone resorption, tartarate-resistant acid phosphatase

JOURNAL FREE ACCESS Advance online publication

Article ID: 70491

DOI https://doi.org/10.1271/bbb.70491

The final version of this article is now available: Vol. 72 (2008) , No. 7 p.1929

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Abstract

We determined the effects of yolk water-soluble protein (YSP) on bone resorption. YSP potently suppressed osteoclastogenesis from bone marrow-derived precursor cells driven by tumor necrosis factor-α (TNF-α). YSP (200 μg/ml) abolished the formation of tartarate-resistant acid phosphatase (TRAP)-positive osteoclasts. Furthermore, TNF-α induced TRAP activity was greatly inhibited by YSP (100 μg/ml) treatment. Our results suggest that YSP has therapeutic potential for bone-erosive diseases.

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