Studies on the Later Stage of the Biosynthesis of Pleuromutilin

Tae TSUKAGOSHI; Tetsuo TOKIWANO; Hideaki OIKAWA

doi:10.1271/bbb.70547

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Studies on the Later Stage of the Biosynthesis of Pleuromutilin

Tae TSUKAGOSHI, Tetsuo TOKIWANO, Hideaki OIKAWA

著者情報

キーワード: pleuromutilin, diterpene biosynthesis, synthesis of ²H-labeled precursor, microbial conversion

ジャーナルフリー早期公開

論文ID: 70547

DOI https://doi.org/10.1271/bbb.70547

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 12 p.3116

詳細

抄録

Mutilin (4) and deoxy analogues 2 and 3 are biosynthetic precursors of pleuromutilin (1) in the later stage of biosynthesis. Precursors 2 and 3 are required for studies on the oxygenation steps in biosynthesis, and were synthesized from readily available 1 via 4 by deoxygenation of the hydroxy groups. Feeding experiments with the ²H-labeled precursors confirmed their microbial conversion into 1.

責任著者(Corresponding author)

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