Differential Regulation of Extracellular Signal-Related Kinase Phosphorylation by Vitamin D3 Analogs

Erina INOUE; Yoshiko ISHIMI; Jun YAMAUCHI

doi:10.1271/bbb.70574

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Differential Regulation of Extracellular Signal-Related Kinase Phosphorylation by Vitamin D₃ Analogs

Erina INOUE, Yoshiko ISHIMI, Jun YAMAUCHI

著者情報

キーワード: vitamin D, nongenomic action, transcription, extracellular signal-related kinase (ERK), chinese hamster ovary (CHO)-K1 cell

ジャーナルフリー早期公開

論文ID: 70574

DOI https://doi.org/10.1271/bbb.70574

この記事には本公開記事があります。

The final version of this article is now available: Vol. 72 (2008) , No. 1 p.246

詳細

抄録

We examined the effects of vitamin D₃ on extracellular signal-related kinase (ERK). 1,25-(OH)₂D₃, a form active in inducing transcription, caused rapid and transient ERK activation. 24R,25-(OH)₂D₃, an inactive form, also activated ERK. In contrast, (22R)-22-methyl-20-epi-1,25-(OH)₂D₃, a synthetic agonist of 1,25-(OH)₂D₃, was not effective. These data provide evidence of selective roles of vitamin D₃ in nongenomic and genomic actions.

責任著者(Corresponding author)

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