Effects of Orally Administered Bovine Lactoperoxidase on Dextran Sulfate Sodium-Induced Colitis in Mice

Kouichirou SHIN; Ayako HORIGOME; Koji YAMAUCHI; Mitsunori TAKASE; Tomoko YAESHIMA; Keiji IWATSUKI

doi:10.1271/bbb.70636

This article has now been updated. Please use the final version.

Effects of Orally Administered Bovine Lactoperoxidase on Dextran Sulfate Sodium-Induced Colitis in Mice

Kouichirou SHIN, Ayako HORIGOME, Koji YAMAUCHI, Mitsunori TAKASE, Tomoko YAESHIMA, Keiji IWATSUKI

Author information

Keywords: lactoperoxidase, colitis, dextran sulphate sodium, interleukin-6

JOURNAL FREE ACCESS Advance online publication

Article ID: 70636

DOI https://doi.org/10.1271/bbb.70636

The final version of this article is now available: Vol. 72 (2008) , No. 7 p.1932

Details

Abstract

The effect of lactoperoxidase (LPO) on dextran sulfate sodium-induced colitis was examined in mice. After 9 d of colitis induction, weight loss, colon shortening, and the histological score were significantly suppressed in mice orally administered LPO (62.5 mg/body/d) as compared to a group administered bovine serum albumin. These results suggest that LPO exhibits anti-inflammatory effects in the gastrointestinal tract.

Corresponding author

Register with J-STAGE for free!