Inhibitory Effects of Whisky Congeners on Melanogenesis in Mouse B16 Melanoma Cells

Kenji OHGUCHI; Minako KOIKE; Yoshihide SUWA; Seiichi KOSHIMIZU; Yuki MIZUTANI; Yoshinori NOZAWA; Yukihiro AKAO

doi:10.1271/bbb.70734

This article has now been updated. Please use the final version.

Inhibitory Effects of Whisky Congeners on Melanogenesis in Mouse B16 Melanoma Cells

Kenji OHGUCHI, Minako KOIKE, Yoshihide SUWA, Seiichi KOSHIMIZU, Yuki MIZUTANI, Yoshinori NOZAWA, Yukihiro AKAO

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Keywords: whisky congeners, melanin, melanogenesis, tyrosinase

JOURNAL FREE ACCESS Advance online publication

Article ID: 70734

DOI https://doi.org/10.1271/bbb.70734

The final version of this article is now available: Vol. 72 (2008) , No. 4 p.1107

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Abstract

We examined the effect of whisky congeners, substances other than ethanol in whisky, on melanogenesis in mouse B16 melanoma cells. Treatment with whisky congeners significantly blocked melanogenesis. Our results indicate that the inhibitory effects of whisky congeners on melanogenesis is due to direct inhibition of tyrosinase activity and to suppression of tyrosinase protein levels.

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