Impact of Spermine on Down-Regulation of Th2 Cytokines in Peripheral Blood Mononuclear Cells from Cedar Pollinosis Subjects in Vitro

Mitsuharu MATSUMOTO; Hiroichi KIMATA; Yoshimi BENNO; Shigenori KAMIO

doi:10.1271/bbb.70795

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Impact of Spermine on Down-Regulation of Th2 Cytokines in Peripheral Blood Mononuclear Cells from Cedar Pollinosis Subjects in Vitro

Mitsuharu MATSUMOTO, Hiroichi KIMATA, Yoshimi BENNO, Shigenori KAMIO

著者情報

キーワード: polyamine, spermine, Th1/Th2, cytokine, cedar pollinosis

ジャーナルフリー早期公開

論文ID: 70795

DOI https://doi.org/10.1271/bbb.70795

この記事には本公開記事があります。

The final version of this article is now available: Vol. 72 (2008) , No. 6 p.1604

詳細

抄録

The effects of spermine (SPM) on the production of Th1 and Th2 cytokines using peripheral blood mononuclear cells (PBMCs) derived from cedar pollinosis subjects were investigated. Th2 cytokines produced by PBMCs stimulated by 10 μM SPM was significantly lower than that in the controls. These findings indicate that blood SPM is an important factor in the Th1/Th2 balance.

責任著者(Corresponding author)

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