Heteroatom-Containing Antibacterial Phenolic Metabolites from a Terrestrial Ampelomyces Fungus

Huiye ZHANG; Haihui XIE; Samuel X. QIU; Jinghua XUE; Xiaoyi WEI

doi:10.1271/bbb.80043

This article has now been updated. Please use the final version.

Heteroatom-Containing Antibacterial Phenolic Metabolites from a Terrestrial Ampelomyces Fungus

Huiye ZHANG, Haihui XIE, Samuel X. QIU, Jinghua XUE, Xiaoyi WEI

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Keywords: filamentous fungus, Ampelomyces, fungal secondary metabolites, sulfur-containing phenol, antibacterial activity

JOURNAL FREE ACCESS Advance online publication

Article ID: 80043

DOI https://doi.org/10.1271/bbb.80043

The final version of this article is now available: Vol. 72 (2008) , No. 7 p.1746

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Abstract

Two new sulfur-containing phenolic compounds, 7-hydroxy-5-hydroxymethyl-2H-benzo[1,4]thiazin-3-one (1) and 2,5-dihydroxy-3-methanesulfinylbenzyl alcohol (2), along with two known compounds, 3-chloro-2,5-dihydroxybenzyl alcohol (3) and 2-hydroxy-6-methylbenzoic acid (4), were isolated from the mycelial solid culture of a soil-derived Ampelomyces fungus by antibacterial assay-guided fractionation. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1–3 showed structure and microbial dependent antibacterial activities.

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