The Formation of Nicotinamide by Administration of Di(2-ethylhexyl)phthalate Does Not Cause Growth Retardation in Young Rats in Contrast with Excess Exogenous Administration of Nicotinamide

Tsutomu FUKUWATARI; Katsumi SHIBATA

doi:10.1271/bbb.80104

This article has now been updated. Please use the final version.

The Formation of Nicotinamide by Administration of Di(2-ethylhexyl)phthalate Does Not Cause Growth Retardation in Young Rats in Contrast with Excess Exogenous Administration of Nicotinamide

Tsutomu FUKUWATARI, Katsumi SHIBATA

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Keywords: nicotinamide, phthalic acid ester, tryptophan, toxicity, di(2-ethylhexyl)phthalate (DEHP)

JOURNAL FREE ACCESS Advance online publication

Article ID: 80104

DOI https://doi.org/10.1271/bbb.80104

The final version of this article is now available: Vol. 72 (2008) , No. 9 p.2423

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Abstract

We investigated the relationship between protein and tryptophan intake and the adverse-effect-level of di(2-ethylhexyl)phthalate (DEHP). Growth retardation of young rats due to DEHP was strengthened by increasing protein level. The addition of tryptophan to the diet caused extreme increases in the nicotinamide formation, but no growth retardation was observed.

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