The Formation of Nicotinamide by Administration of Di(2-ethylhexyl)phthalate Does Not Cause Growth Retardation in Young Rats in Contrast with Excess Exogenous Administration of Nicotinamide

Tsutomu FUKUWATARI; Katsumi SHIBATA

doi:10.1271/bbb.80104

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The Formation of Nicotinamide by Administration of Di(2-ethylhexyl)phthalate Does Not Cause Growth Retardation in Young Rats in Contrast with Excess Exogenous Administration of Nicotinamide

Tsutomu FUKUWATARI, Katsumi SHIBATA

著者情報

キーワード: nicotinamide, phthalic acid ester, tryptophan, toxicity, di(2-ethylhexyl)phthalate (DEHP)

ジャーナルフリー早期公開

論文ID: 80104

DOI https://doi.org/10.1271/bbb.80104

この記事には本公開記事があります。

The final version of this article is now available: Vol. 72 (2008) , No. 9 p.2423

詳細

抄録

We investigated the relationship between protein and tryptophan intake and the adverse-effect-level of di(2-ethylhexyl)phthalate (DEHP). Growth retardation of young rats due to DEHP was strengthened by increasing protein level. The addition of tryptophan to the diet caused extreme increases in the nicotinamide formation, but no growth retardation was observed.

責任著者(Corresponding author)

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