Validation of an Ion Trap Tandem Mass Spectrometric Analysis of Mulberry 1-Deoxynojirimycin in Human Plasma: Application to Pharmacokinetic Studies

Kiyotaka NAKAGAWA; Hiroyuki KUBOTA; Tsuyoshi TSUZUKI; Jun KARIYA; Toshiyuki KIMURA; Shinichi OIKAWA; Teruo MIYAZAWA

doi:10.1271/bbb.80200

This article has now been updated. Please use the final version.

Validation of an Ion Trap Tandem Mass Spectrometric Analysis of Mulberry 1-Deoxynojirimycin in Human Plasma: Application to Pharmacokinetic Studies

Kiyotaka NAKAGAWA, Hiroyuki KUBOTA, Tsuyoshi TSUZUKI, Jun KARIYA, Toshiyuki KIMURA, Shinichi OIKAWA, Teruo MIYAZAWA

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Keywords: mulberry, 1-deoxynojirimycin, tandem mass spectrometry, absorption, human plasma

JOURNAL FREE ACCESS Advance online publication

Article ID: 80200

DOI https://doi.org/10.1271/bbb.80200

The final version of this article is now available: Vol. 72 (2008) , No. 8 p.2210

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Abstract

Mulberry 1-deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor. Although it is useful for the treatment of diabetes, the human absorption and metabolism of DNJ have never been characterized. We developed a method using hydrophilic interaction chromatography coupled with ion trap tandem mass spectrometry, and found that orally administered DNJ was absorbed into the blood and then excreted into the urine.

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