Preventive Effect of Streptococcus thermophilus YIT 2001 on Dextran Sulfate Sodium-Induced Colitis in Mice

Masahiko ITO; Kenji OHISHI; Yasuto YOSHIDA; Takekazu OKUMURA; Tadashi SATO; Wakae YOKOI; Haruji SAWADA

doi:10.1271/bbb.80240

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Preventive Effect of Streptococcus thermophilus YIT 2001 on Dextran Sulfate Sodium-Induced Colitis in Mice

Masahiko ITO, Kenji OHISHI, Yasuto YOSHIDA, Takekazu OKUMURA, Tadashi SATO, Wakae YOKOI, Haruji SAWADA

著者情報

キーワード: lactic acid bacteria, oxidative injury, dextran sulfate sodium, ulcerative colitis, antioxidative activity

ジャーナルフリー早期公開

論文ID: 80240

DOI https://doi.org/10.1271/bbb.80240

この記事には本公開記事があります。

The final version of this article is now available: Vol. 72 (2008) , No. 10 p.2543

詳細

抄録

We investigated the preventive effect of Streptococcus thermophilus YIT 2001, a lactic acid bacterum having high antioxidative activity, on acute colitis induced by 2.5% dextran sulfate sodium in mice, and compared the effect with that of S. thermophilus YIT 2084 which has lower antioxidative activity. Feeding S. thermophilus YIT 2001 decreased the disease activity index and level of lipid peroxide (the thiobarbituric acid reactive substance content) in the colonic mucosa. The hematocrit and hemoglobin concentrations in the blood of S. thermophilus YIT 2001-fed mice were higher than those of the control mice. S. thermophilus YIT 2084 had no significant effect on these parameters. The results suggest that the antioxidative activity of S. thermophilus YIT 2001 was involved in the improving effect on colitis.

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