Oral Administration of Lactobacillus plantarum NRIC0380 Suppresses IgE Production and Induces CD4⁺CD25⁺Foxp3⁺ Cells in Vivo

Abstract

The influence of lactic acid bacteria (LAB) on CD4⁺Foxp3⁺ cells has not been investigated, although it has been reported that CD4⁺Foxp3⁺ cells might be involved in the inhibition of allergic symptoms. Hence we examined the effect of orally administered LAB on CD4⁺Foxp3⁺ generation. Oral administration of Lactobacillus plantarum NRIC0380 significantly inhibited antigen-specific IgE production and enhanced the Th1 response, as some other strains reported in previous studies. The ratio of CD4⁺CD25⁺Foxp3⁺ cells in whole CD4⁺ cells was significantly higher in both Peyer’s patch and the spleen of mice that had been fed with LAB than in the control mice.