A Novel <small>L</small>-Amino Acid Ligase Is Encoded by a Gene in the Phaseolotoxin Biosynthetic Gene Cluster from Pseudomonas syringae pv. phaseolicola 1448A

Toshinobu ARAI; Kuniki KINO

doi:10.1271/bbb.80439

This article has now been updated. Please use the final version.

A Novel L-Amino Acid Ligase Is Encoded by a Gene in the Phaseolotoxin Biosynthetic Gene Cluster from Pseudomonas syringae pv. phaseolicola 1448A

Toshinobu ARAI, Kuniki KINO

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Keywords: L-amino acid ligase, peptide synthesis, phaseolotoxin

JOURNAL FREE ACCESS Advance online publication

Article ID: 80439

DOI https://doi.org/10.1271/bbb.80439

The final version of this article is now available: Vol. 72 (2008) , No. 11 p.3048

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Abstract

In the phaseolotoxin biosynthetic gene cluster of Pseudomonas syringae pv. phaseolicola 1448A, the PSPPH_4299 gene encodes a novel L-amino acid ligase. The PSPPH_4299 protein synthesized various hetero-dipeptides containing basic amino acids in an ATP-dependent manner, and also synthesized alanyl-homoarginine, part of the phaseolotoxin scaffold.

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