Disruption of Lipid Rafts Enhances the Effect of Lactobacilli on the Production of Tumor Necrosis Factor-Alpha in Mononuclear Blood Cells

Mario SORIA; Mónica MECHOUD; Angela MARTIN DE QUEVEDO; Graciela FONT DE VALDEZ; Ana V.RODRIGUEZ

doi:10.1271/bbb.80445

This article has now been updated. Please use the final version.

Disruption of Lipid Rafts Enhances the Effect of Lactobacilli on the Production of Tumor Necrosis Factor-Alpha in Mononuclear Blood Cells

Mario SORIA, Mónica MECHOUD, Angela MARTIN DE QUEVEDO, Graciela FONT DE VALDEZ, Ana V.RODRIGUEZ

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Keywords: lactobacilli, lipid rafts, tumor necrosis factor-alpha

JOURNAL FREE ACCESS Advance online publication

Article ID: 80445

DOI https://doi.org/10.1271/bbb.80445

The final version of this article is now available: Vol. 72 (2008) , No. 12 p.3293

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Abstract

We investigated, to determine whether disruption of lipid rafts would influence the effect of three selected strains of Lactobacillus on TNF-alpha production by peripheral blood mononuclear cells. Two strains increased TNF-alpha production; and the third one reduced cytokine levels. Disruption of rafts changed the immunomodulatory effect of the three strains. This is the first report on a potential role of rafts in lactobacilli-cell interaction.

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