Accumulation of the Bioactive Peptides, Novokinin, LPYPR and Rubiscolin, in Seeds of Genetically Modified Soybean

Keito NISHIZAWA; Akiko KITA; Chieko DOI; Yuko YAMADA; Kousaku OHINATA; Masaaki YOSHIKAWA; Masao ISHIMOTO

doi:10.1271/bbb.80468

This article has now been updated. Please use the final version.

Accumulation of the Bioactive Peptides, Novokinin, LPYPR and Rubiscolin, in Seeds of Genetically Modified Soybean

Keito NISHIZAWA, Akiko KITA, Chieko DOI, Yuko YAMADA, Kousaku OHINATA, Masaaki YOSHIKAWA, Masao ISHIMOTO

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Keywords: bioactive peptide, bioreactor, dietetic therapy, molecular farming, transgenic soybean

JOURNAL FREE ACCESS Advance online publication

Article ID: 80468

DOI https://doi.org/10.1271/bbb.80468

The final version of this article is now available: Vol. 72 (2008) , No. 12 p.3301

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Abstract

Novokinin (RPLKPW), LPYPR, and rubiscolin (YPLDLF) are bioactive peptides with respective hypotensive, hypocholesterolemic, and memory-enhancing activities. We generated transgenic soybean lines that expressed modified forms of the α′ subunit of seed storage protein β-conglycinin containing tandem repeats of these bioactive peptides. The modified α′ subunits constituted up to 0.2% of extracted proteins from the transgenic seeds.

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