Effects of Long-Term Administration of Royal Jelly on Pituitary Weight and Gene Expression in Middle-Aged Female Rats

Yukio NARITA; Shozo OHTA; Kazu-Michi SUZUKI; Tomoko NEMOTO; Keiko ABE; Satoshi MISHIMA

doi:10.1271/bbb.80556

This article has now been updated. Please use the final version.

Effects of Long-Term Administration of Royal Jelly on Pituitary Weight and Gene Expression in Middle-Aged Female Rats

Yukio NARITA, Shozo OHTA, Kazu-Michi SUZUKI, Tomoko NEMOTO, Keiko ABE, Satoshi MISHIMA

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Keywords: royal jelly, pituitary, prolactin, aging, thyroid-stimulating hormone β

JOURNAL FREE ACCESS Advance online publication

Article ID: 80556

DOI https://doi.org/10.1271/bbb.80556

The final version of this article is now available: Vol. 73 (2009) , No. 2 p.431

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Abstract

To determine the effects of ingested royal jelly (RJ) on the pituitary in middle-aged female rats, we performed a long-term RJ administration test. Several animals showed age-related increases in pituitary weight, and RJ administration compensated for the increase. RJ tended to down-regulate prolactin mRNA and up-regulated thyroid-stimulating hormone β mRNA in the pituitary. This suggests that RJ compensates for age-associated decline in pituitary functions.

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