The Sulfated Polysaccharide Porphyran Reduces Apolipoprotein B100 Secretion and Lipid Synthesis in HepG2 Cells

Nao INOUE; Naomi YAMANO; Kotaro SAKATA; Koji NAGAO; Yoichiro HAMA; Teruyoshi YANAGITA

doi:10.1271/bbb.80688

This article has now been updated. Please use the final version.

The Sulfated Polysaccharide Porphyran Reduces Apolipoprotein B100 Secretion and Lipid Synthesis in HepG2 Cells

Nao INOUE, Naomi YAMANO, Kotaro SAKATA, Koji NAGAO, Yoichiro HAMA, Teruyoshi YANAGITA

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Keywords: porphyran, apolipoprotein B100, lipid synthesis, HepG2

JOURNAL FREE ACCESS Advance online publication

Article ID: 80688

DOI https://doi.org/10.1271/bbb.80688

The final version of this article is now available: Vol. 73 (2009) , No. 2 p.447

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Abstract

The physiological effect of porphyran, a sulfated polysaccharides from an edible red alga, was studied in human hepatoma HepG2 cells. Porphyran supplementation significantly decreased apolipoprotein B100 secretion, and the reduction was partly associated with suppression of cellular lipid synthesis in HepG2 cells. This is the first study to elusidate the mechanism of the hypolipidemic effect of porphyran.

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