Isolation of Antibabesial Compounds from Brucea javanica, Curcuma xanthorrhiza, and Excoecaria cochinchinensis

Kazuaki YAMADA; SUBEKI; Kensuke NABETA; Masahiro YAMASAKI; Ken KATAKURA; Hideyuki MATSUURA

doi:10.1271/bbb.80784

This article has now been updated. Please use the final version.

Isolation of Antibabesial Compounds from Brucea javanica, Curcuma xanthorrhiza, and Excoecaria cochinchinensis

Kazuaki YAMADA, SUBEKI, Kensuke NABETA, Masahiro YAMASAKI, Ken KATAKURA, Hideyuki MATSUURA

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Keywords: Babesia gibsoni, antibabesial compound, Curcuma xanthorrhiza, Brucea javanica, Excoecaria cochinchinensis

JOURNAL FREE ACCESS Advance online publication

Article ID: 80784

DOI https://doi.org/10.1271/bbb.80784

The final version of this article is now available: Vol. 73 (2009) , No. 3 p.776

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Abstract

One new curcuminoid, 3′-demethoxycyclocurcumin (1), was isolated from Curcuma xanthorrhiza as an antibabesial compound, together with p-hydroxybenzaldehyde (2) and cleomiscosin A (3) from Brucea javanica and (+)-epiloliolide (4) from Excoecaria cochinchinensis. The antibabesial activities were examined in vitro, and compounds 1–4, and diminazene aceturate were studied with IC₅₀ values of 16.6, 7.6, 15.6, 10.0, and 0.6 μg/ml, respectively.

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