Effective Synthesis of Optically Active Trifluoromethyldiazirinyl Homophenylalanine and Aroylalanine Derivatives with the Friedel-Crafts Reaction in Triflic Acid

Ryo MURASHIGE; Yuta MURAI; Yasumaru HATANAKA; Makoto HASHIMOTO

doi:10.1271/bbb.90027

This article has now been updated. Please use the final version.

Effective Synthesis of Optically Active Trifluoromethyldiazirinyl Homophenylalanine and Aroylalanine Derivatives with the Friedel-Crafts Reaction in Triflic Acid

Ryo MURASHIGE, Yuta MURAI, Yasumaru HATANAKA, Makoto HASHIMOTO

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Keywords: diazirine, photoaffinity labeling, Friedel-Crafts reaction, triflic acid

JOURNAL FREE ACCESS Advance online publication

Article ID: 90027

DOI https://doi.org/10.1271/bbb.90027

The final version of this article is now available: Vol. 73 (2009) , No. 6 p.1377

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Abstract

The Friedel-Crafts reaction with 3-(3-methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine and optically active N-TFA-Asp(Cl)-OMe in triflic acid afforded homophenylalanine derivatives without any loss of the optical purity.

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