Synthetic Approach to Telomerase Inhibitor Dictyodendrin B: Synthesis of the Pyrrolo[2,3-c]carbazole Core

Abstract

The core structure of the telomerase inhibitor, dictyodendrin B, was synthesized by using the palladium-catalyzed cross-coupling reaction of 3-aryl-1-(2-arylethyl)-4-hydroxy-2,5-bismethoxycarbonylpyrrole triflate with 7-alkoxyindole-3-boronate as the key step.