Inhibitive Effects of Alkyl Gallates on Hyaluronidase and Collagenase

Florin BARLA; Hayato HIGASHIJIMA; Shingo FUNAI; Keiichiro SUGIMOTO; Naoki HARADA; Ryoichi YAMAJI; Tomoyuki FUJITA; Yoshihisa NAKANO; Hiroshi INUI

doi:10.1271/bbb.90365

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Inhibitive Effects of Alkyl Gallates on Hyaluronidase and Collagenase

Florin BARLA, Hayato HIGASHIJIMA, Shingo FUNAI, Keiichiro SUGIMOTO, Naoki HARADA, Ryoichi YAMAJI, Tomoyuki FUJITA, Yoshihisa NAKANO, Hiroshi INUI

著者情報

キーワード: alkyl gallates, hyaluronidase inhibitory activity, collagenase inhibitory activity, antioxidant activity

ジャーナルフリー早期公開

論文ID: 90365

DOI https://doi.org/10.1271/bbb.90365

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2009) , No. 10 p.2335

詳細

抄録

A series of the gallate esters of n-alkanols (C₁–C₁₂) was examined to determine their inhibitory activities against hyaluronidase and collagenase. Hexyl, heptyl, octyl, nonyl, and decyl gallates inhibited both hyaluronidase and collagenase, and the most potent inhibitor was octyl gallate against both enzymes. Octyl 3,5-dihydroxybenzoate showed inhibitory effects on hyaluronidase, whereas collagenase was inhibited by octyl 3,4-dihydroxybenzoate.

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